Year
2016
Season
Spring
Paper Type
Master's Thesis
College
College of Arts and Sciences
Degree Name
Master of Science (MS)
Department
Biology
NACO controlled Corporate Body
University of North Florida. Department of Biology
First Advisor
Dr. David S. Waddell
Second Advisor
Dr. John D. Hatle
Third Advisor
Dr. Terri N. Ellis
Department Chair
Dr. Cliff Ross
College Dean
Dr. Barbara A. Hetrick
Abstract
Skeletal muscle atrophy can occur at any age and as a result of numerous physiological conditions and thus, it was necessary to better identify the molecular underpinnings of the atrophy cascade so that new therapeutic targets to treat muscle wasting might be identified. MuRF1 was first identified as a marker of skeletal muscle atrophy over a decade ago; however, recent work suggests that this E3 ubiquitin ligase may participate in muscle wasting by regulating the transcriptional activity of genes differentially expressed in response to muscle atrophy. Dusp4, a dual-specificity phosphatase and member of the MAPK cascade, is induced in response to neurogenic atrophy; however, this induction is significantly blunted in the MuRF1-null mice which are resistant to muscle atrophy. The research presented in this thesis aims to characterize the mechanism by which MuRF1 may transcriptionally regulate Dusp4 and characterizes the function of Dusp4 in skeletal muscle.
Suggested Citation
Haddock, Ashley Noel, "Transcriptional Regulation of Dual-Specificity Phosphatase 4 (Dusp4) by Muscle RING Finger 1 (MuRF1) and Myogenic Regulatory Factors" (2016). UNF Graduate Theses and Dissertations. 618.
https://digitalcommons.unf.edu/etd/618