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Volume VI, 2007

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Diet is the only environmental variable that has been shown to slow aging. Late-onset caloric restriction results in increased longevity in female grasshoppers. To better
understand the physiological processes involved, and how rapid the responses can occur, we studied the effect of diet on total fat body protein. We tested the effects of short-term treatments on the amount of fat body protein for day 20 and day 50 of adulthood: ad libitum feeding (free access to food), starvation (only water), caloric restriction (1.5g of lettuce) and heat shocking (60 min at 48°C). Grasshoppers were initially fed ad libitum and then switched to diet treatments 48 h before fat body removal. We found that day 20 grasshoppers had more fat body protein than day 50 grasshoppers. At day 20, but not at day 50, ad libitum feeding produced higher levels of fat body protein than other diets. Our results suggest that total fat body protein is not one of the physiological responses that produce longer lifespan when organisms are on a caloric restriction diet.

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