Volume I, 2001
Dr. Doria F. Bowers
This paper discusses the extracellular matrix (ECM) and its involvement in organogenesis. Research was conducted to examine the ECM characteristics in avian cerebella. Specifically, the investigator wanted to demonstrate the presence of collagen fibrils associated with the surface of fissures in embryonic day-10 chick cerebella by using immunochemical analysis. The results of laboratory work completed thus far are inconclusive and suggest that the methodology of the immunolabelling portion of these experiments needs modification. It is suspected the autofluorescence was detected and if changes in the procedure fully account for this artifact, another assay's immunochemicals may recognize a highly aligned distribution of collagen fibrils (or other ECM component) in the floor of cerebellar fissures. These findings would further the investigation of ECM's role in morphogenetic tissue interactions.
McLeod, Colleen, "Extracellular Matrix Characteristics of Embryonic Avian Cerebella" (2001). All Volumes (2001-2008). 48.