The Short Allele of the Serotonin Transporter Gene (SLC6A4) Increases Predisposition to Anxiety and Negative Emotional States

Authors

Gabriella Hitti, University of North FloridaFollow

Faculty Mentor

Marie Mooney PhD

Faculty Mentor Department

Biology Department

Abstract

Mental disorders, such as anxiety and mood disorders, have long been a focus of psychological research, and increasing evidence points to a genetic basis for their occurrence. Polymorphisms of the serotonin transporter (5-HTT) gene (SLC6A4) may predispose an individual to anxiety-related symptoms. SLC6A4 has two common alleles: the short (s) allele, which results in less 5-HTT protein production, and the long (l) allele, which results in more 5-HTT. Integrated findings from psychometric evaluations, behavioral animal models, and biological assessments establish a link between the s allele of SLC6A4 and heightened anxiety phenotypes. The allele’s influence on serotonin levels and brain structures like the amygdala suggests its importance in emotional processing. With advancements in gene-editing technologies, targeting SLC6A4 polymorphisms offers a promising approach for personalized treatment of anxiety and related disorders. However, gaps in understanding demographic variations and their influence on the gene’s expression call for further investigation.

Recommended Citation

Hitti, Gabriella (2024) "The Short Allele of the Serotonin Transporter Gene (SLC6A4) Increases Predisposition to Anxiety and Negative Emotional States," PANDION: The Osprey Journal of Research and Ideas: Vol. 5: No. 1, Article 4.
Available at: https://digitalcommons.unf.edu/pandion_unf/vol5/iss1/4