Faculty Sponsor

Dr. Amy Lane

Faculty Sponsor College

College of Arts and Sciences

Faculty Sponsor Department

Biology

Location

SOARS Virtual Conference

Presentation Website

https://unfsoars.domains.unf.edu/manipulation-of-cellular-machinery-to-produce-anti-cancer-drugs/

Keywords

SOARS (Conference) (2020 : University of North Florida) -- Posters; University of North Florida. Office of Undergraduate Research; University of North Florida. Graduate School; College students – Research -- Florida – Jacksonville -- Posters; University of North Florida – Undergraduates -- Research -- Posters; University of North Florida. Department of Biology -- Research -- Posters; Biology, Physics, and Chemistry -- Research – Posters

Abstract

The nocardioazine natural products are uniquely prenylated and methylated indole alkaloid diketopiperazines (DKPs) that reverse drug resistance of cancer cell lines. We unveiled the nocardioazine biosynthetic pathway from a marine actinomycete, demonstrating that a cyclodipeptide synthase catalyzes cyclo(L-Trp-L-Trp) DKP precursor formation followed by tailoring of this DKP via a novel racemase, prenyltransferase, and methyltransferase to yield nocardioazine B. These results highlight the aptitude of bacteria for chemical synthesis and offer new enzymatic tools for crafting complex organic molecules.

Included in

Biology Commons

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Apr 8th, 12:00 AM Apr 8th, 12:00 AM

Manipulation of Cellular Machinery to Produce Anti-cancer Drugs

SOARS Virtual Conference

The nocardioazine natural products are uniquely prenylated and methylated indole alkaloid diketopiperazines (DKPs) that reverse drug resistance of cancer cell lines. We unveiled the nocardioazine biosynthetic pathway from a marine actinomycete, demonstrating that a cyclodipeptide synthase catalyzes cyclo(L-Trp-L-Trp) DKP precursor formation followed by tailoring of this DKP via a novel racemase, prenyltransferase, and methyltransferase to yield nocardioazine B. These results highlight the aptitude of bacteria for chemical synthesis and offer new enzymatic tools for crafting complex organic molecules.

https://digitalcommons.unf.edu/soars/2020/spring_2020/66

 

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