Title

Brain metastases-derived extracellular vesicles induce binding and aggregation of low-density lipoprotein

Document Type

Article

Publication Date

12-1-2020

Subject Area

ARRAY(0x5573733b6d58)

Abstract

Background: Cancer cell-derived extracellular vesicles (EVs) have previously been shown to contribute to pre-metastatic niche formation. Specifically, aggressive tumors secrete pro-metastatic EVs that travel in the circulation to distant organs to modulate the microenvironment for future metastatic spread. Previous studies have focused on the interface between pro-metastatic EVs and epithelial/endothelial cells in the pre-metastatic niche. However, EV interactions with circulating components such as low-density lipoprotein (LDL) have been overlooked. Results: This study demonstrates that EVs derived from brain metastases cells (Br-EVs) and corresponding regular cancer cells (Reg-EVs) display different interactions with LDL. Specifically, Br-EVs trigger LDL aggregation, and the presence of LDL accelerates Br-EV uptake by monocytes, which are key components in the brain metastatic niche. Conclusions: Collectively, these data are the first to demonstrate that pro-metastatic EVs display distinct interactions with LDL, which impacts monocyte internalization of EVs. [Figure not available: see fulltext.]

Publication Title

Journal of Nanobiotechnology

Volume

18

Issue

1

Digital Object Identifier (DOI)

10.1186/s12951-020-00722-2

PubMed ID

33160390

E-ISSN

14773155

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