Year of Publication
Season of Publication
Brooks College of Health
Doctor of Nursing Practice (DNP)
NACO controlled Corporate Body
University of North Florida. School of Nursing
Dr. Doreen Radjenovic
Dr. Carol Ledbetter
Dr. Dan Richard
Dr. Jonathan Pabalate
Dr. Lillia Loriz
Dr. Pamela S. Chally
Since the first so-called “medical marijuana” legislation was passed in California in 1996, a total of twenty states and the District of Columbia have passed laws permitting limited use of cannabis. Despite the changes in state laws, cannabis remains illegal for any purpose under federal law. Changes in state laws have coincided with a renewed interest in the substance for the treatment of a variety of conditions. There has been a significant increase in published data over the past twenty years examining the efficacy of cannabis as an appetite stimulant, antiemetic agent, and analgesic adjuvant. The purpose of this meta-analysis was to synthesize published data on cannabis use as an analgesic agent. Five studies meeting inclusion criteria were located through searches of online databases, review of reference lists, author correspondence, and review of clinical trials databases. Meta-analysis was conducted using fixed-effects modeling. The overall effect of mean reduction of pain intensity was -4.895 (Z-score) with an associated p value of 0.003. The combined standardized mean difference (SMD) was -0.362 (CI -0.507 to -0.217), indicating on average a moderate significant reduction in pain intensity for patients with chronic pain. As the legal status of the substance evolves, additional research is needed to establish evidence-based clinical recommendations regarding the use of medicinal cannabis in pain management.
Seneca, Michael J., "Meta-Analysis of Herbal Cannabis Therapy for Chronic Pain" (2014). UNF Theses and Dissertations. 503.
Medical Pharmacology Commons, Medicinal and Pharmaceutical Chemistry Commons, Natural Products Chemistry and Pharmacognosy Commons, Nursing Commons, Pharmacy Administration, Policy and Regulation Commons