Paper Type

Master's Thesis


Brooks College of Health

Degree Name

Master of Science in Nursing (MSN)



First Advisor

Dr. Kathaleen C. Bloom

Second Advisor

Dr. M. Catherine Hough

Third Advisor

Dr. Lillia Loriz


Lung transplant is a treatment modality for patients with end stage lung disease. Bronchiolitis obliterans syndrome (BOS) is the number one cause of morbidity and mortality in patients the first year after lung transplant. There are many risk factors which have been identified to increase the risk of BOS including acute rejection, lymphocytic bronchitis, medication non-compliance, bacterial or viral infections, older donor age, extended ischemic time, donor antigen-specific reactivity, human leukocyte antigen (HLA) mismatch, underlying disease and gastroesophageal reflux disease (GERD).

Advanced practice nurses can help in the primary prevention of BOS through the assessment and treatment of pre-transplant patients with GERD. A descriptive study using retrospective chart reviews of lung transplant recipients was conducted to evaluate the relationship between pre-transplant GERD and post-transplant BOS. The incidence of pre-transplant GERD was 39%. The incidence of BOS at year one was 17% and at year two was 32%. There was not a significant relationship between pre-transplant GERD and post-transplant BOS.

Included in

Nursing Commons