The Associations between Increasing Degrees of HOMA-IR and Measurements of Adiposity among Euglycemic U.S. Adults
Background: The purpose of this study was to examine the associations between increasing degrees of insulin resistance (using the homeostatic model assessment of insulin resistance [HOMA-IR]) and two measures of adiposity in a nationally representative sample of euglycemic U.S. adults. Materials and Methods: Sample included adult participants (≥20 years of age) [N = 1586 (body mass index, BMI model), N = 1577 (waist circumference, WC model)] from the 1999-2004 National Health and Nutrition Examination Survey (NHANES). HOMA-IR was categorized into quartiles. BMI and WC were examined continuously as the dependent variables. Results: Following adjustment for covariates, those with HOMA-IR values in the second, third, and fourth quartiles had significantly higher BMIs (P < 0.001) compared with subjects in the first quartile. In the model using WC, significantly higher WCs were found in subjects in the second, third, and fourth quartiles of HOMA-IR (P < 0.001) compared with those in the first quartile. A significant moderate correlation was found between HOMA-IR and BMI (R2 = 0.4171, P < 0.001), as well as HOMA-IR and WC (R2 = 0.4826, P < 0.001). Conclusions: Having a higher HOMA-IR value is associated with higher BMI and WC values in euglycemic subjects.
Metabolic Syndrome and Related Disorders
Digital Object Identifier (DOI)
Boyer, Johnson, T. M., Fitzhugh, E. C., Richardson, M. R., & Churilla, J. R. (2016). The Associations Between Increasing Degrees of HOMA-IR and Measurements of Adiposity Among Euglycemic U.S. Adults. Metabolic Syndrome and Related Disorders, 14(2), 18–113. https://doi.org/10.1089/met.2015.0077