[bmim(SO3H)][OTf]/[bmim][X] and Zn(NTf2)2/[bmim][X] (X = PF6and BF4); Efficient catalytic systems for the synthesis of tetrahydropyrimidin-ones (-thiones) via the Biginelli reaction

Authors

Hemantkumar M. Savanur, Karnatak University
Rajesh G. Kalkhambkar, Karnatak University
Gopalakrishnan Aridoss, University of North FloridaFollow
Kenneth K. Laali, University of North FloridaFollow

Document Type

Article

Publication Date

1-1-2016

Abstract

A facile, high yielding, and simple method for the synthesis of a library of dihydropyrimidinones (and -thiones) via the one-pot Biginelli reaction of aldehydes is reported. The method employs the Brønsted acidic IL [bmim(SO3H][OTf] or Zn(NTf2)2as catalyst along with the readily available imidazolium-ILs as solvent, and exhibits good potential for the recycling and reuse of the IL solvent.

Publication Title

Tetrahedron Letters

Volume

57

Issue

27-28

First Page

3029

Last Page

3035

Digital Object Identifier (DOI)

10.1016/j.tetlet.2016.05.103

ISSN

00404039

E-ISSN

18733581

Citation Information

Savanur, H.M., Kalkhambkar, R.G., Aridoss, G., & Laali, K.K. (2016). [bmim(SO3H)][OTf]/[bmim][X] and Zn(NTf2)2/[bmim][X] (X = PF6 and BF4); efficient catalytic systems for the synthesis of tetrahydropyrimidin-ones (-thiones) via the Biginelli reaction. Tetrahedron Letters, 57, 3029-3035.