Title

Lipoprotein-based drug delivery

Document Type

Article

Publication Date

1-1-2020

Subject Area

ARRAY(0x557374ec3bb8)

Abstract

Lipoproteins (LPs) are circulating heterogeneous nanoparticles produced by the liver and intestines. LPs play a major role in the transport of dietary and endogenous lipids to target cells through cell membrane receptors or cell surface-bound lipoprotein lipase. The stability, biocompatibility, and selective transport of LPs make them promising delivery vehicles for various therapeutic and imaging agents. This review discusses isolation, manufacturing, and drug loading techniques used for LP-based drug delivery, as well as recent applications for diagnosis and treatment of cancer, atherosclerosis, and other life-threatening diseases.

Publication Title

Advanced Drug Delivery Reviews

Volume

159

First Page

377

Last Page

390

Digital Object Identifier (DOI)

10.1016/j.addr.2020.08.003

PubMed ID

32791075

ISSN

0169409X

E-ISSN

18728294

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