Lipoprotein-based drug delivery

Authors

Sara Busatto, Mayo Clinic in Jacksonville, Florida
Sierra A. Walker, Mayo Clinic in Jacksonville, Florida
Whisper Grayson, University of North Florida
Anthony Pham, Mayo Clinic in Jacksonville, Florida
Ming Tian, Mayo Clinic in Jacksonville, Florida
Nicole Nesto, University of North Florida
Jacqueline Barklund, University of North Florida
Joy Wolfram, Mayo Clinic in Jacksonville, Florida

Document Type

Article

Publication Date

1-1-2020

Abstract

Lipoproteins (LPs) are circulating heterogeneous nanoparticles produced by the liver and intestines. LPs play a major role in the transport of dietary and endogenous lipids to target cells through cell membrane receptors or cell surface-bound lipoprotein lipase. The stability, biocompatibility, and selective transport of LPs make them promising delivery vehicles for various therapeutic and imaging agents. This review discusses isolation, manufacturing, and drug loading techniques used for LP-based drug delivery, as well as recent applications for diagnosis and treatment of cancer, atherosclerosis, and other life-threatening diseases.

Publication Title

Advanced Drug Delivery Reviews

Volume

159

First Page

377

Last Page

390

Digital Object Identifier (DOI)

10.1016/j.addr.2020.08.003

PubMed ID

32791075

ISSN

0169409X

E-ISSN

18728294

Citation Information

Busatto, S., Walker, S. A., Grayson, W., Pham, A., Tian, M., Nesto, N., Barklund, J., & Wolfram, J. (2020). Lipoprotein-based drug delivery. Advanced drug delivery reviews, 159, 377–390. https://doi.org/10.1016/j.addr.2020.08.003