The effect of maternal intact protein-and amino acid-based diets on development of food intake regulatory systems and body weight in dams and male offspring of wistar rats
Document Type
Article
Publication Date
4-1-2019
Abstract
The objective of this study is to examine the effect of maternal and weaning intact protein-and amino acid-based diets on regulation of food intake, intake regulatory hormones, and body weight in dams and their male offspring. Pregnant Wistar rats were allocated to two groups (n = 12) and were fed either an intact protein diet (IPD) or mixed amino acid diet (AAD) from day 3 of gestation throughout gestation and lactation. Male offspring were weaned to either an IPD or AAD for 18 weeks. Food intake (FI) and body weight (BW) were measured weekly. Results: In dams, the AAD group had lower FI and BW in the post-partum period compared with the IPD group. In pups born to AAD dams, birth weight and BW were lower. However, the percentage of fat and lean mass were not affected. Food intake was influenced by maternal diet and was higher in pups born to IPD dams throughout post-weaning. Short-term FI in response to protein preloads was lower in pups born to AAD dams in 1 h. Fasting plasma concentrations of glucose, insulin, and ghrelin were not influenced by either maternal or weaning diet. However, peptide YY (PYY) was higher in pups born to IPD dams at weaning. Conclusions: The physicochemical properties of proteins fed during pregnancy and lactation had determining effects on the body weight and development of food intake regulatory systems in offspring. Maternal AAD resulted in lower BW in dams and lower birth weight and post-weaning BWs in pups compared with maternal IPD which was consistent with their lower FI.
Publication Title
International Journal of Molecular Sciences
Volume
20
Issue
7
Digital Object Identifier (DOI)
10.3390/ijms20071690
PubMed ID
30987357
ISSN
16616596
E-ISSN
14220067
Citation Information
Jahan-Mihan, A. (2019) The Effect of Maternal Intact Protein-and Amino Acid-based Diets on Development of Food Intake Regulatory Systems and Body Weight in Dams and Male Offspring of Wistar Rats. International Journal of Molecular Sciences, 20(7), 1690.