Simulating Transplant Small-for-size Grafts Using Human Liver Monosegments: The Impact of Portal Perfusion Pressure

Authors

M. Mohamed, Mayo Clinic in Jacksonville, Florida
L. Kang, Mayo Clinic in Jacksonville, Florida
C. Zhang, Mayo Clinic in Jacksonville, Florida
B. Edenfield, Mayo Clinic in Jacksonville, Florida
J. Sykes, Mayo Clinic in Jacksonville, Florida
T. Brown, Mayo Clinic in Jacksonville, Florida
J. L. Johnson, Mayo Clinic in Jacksonville, Florida
F. Rehman, University of North FloridaFollow
J. H. Nguyen, Mayo Clinic in Jacksonville, Florida

Document Type

Article

Publication Date

4-1-2019

Abstract

Small-for-size-liver grafts (SFSG) in adult transplant recipients have elevated risk of graft failure, limiting its application in clinical liver transplantation. Relevant preclinical model of SFSG is lacking. Relevant to deceased-donor split liver transplant and living-donor liver transplant in adult recipients, in this study, we present our initial characterization of SFSG model using monosegments of a discarded human donor liver.

Publication Title

Transplantation Proceedings

Volume

51

Issue

3

First Page

919

Last Page

924

Digital Object Identifier (DOI)

10.1016/j.transproceed.2018.12.028

PubMed ID

30737025

ISSN

00411345

E-ISSN

18732623

Citation Information

M. Mohamed, L. Kang, C. Zhang, B. Edenfield, J. Sykes, T. Brown, J. L. Johnson, F. Rehman, J. H. Nguyen. (2019) Simulating Transplant Small-for-size Grafts Using Human Liver Monosegments: The Impact of Portal Perfusion Pressure. Transplantation Proceedings, 51(3), 919-924.