Title

Facile Access to Diverse Libraries of Internal Alkynes via Sequential Iododediazoniation/Decarboxylative Sonogashira Reaction in Imidazolium ILs without Ligand or Additive

Document Type

Article

Publication Date

3-14-2019

Subject Area

ARRAY(0x55b6a6ad31f0)

Abstract

Convenient access to diverse libraries of internal alkynes via decarboxylative Sonogashira reaction of alkynyl-carboxylic acids with iodoarenes, employing imidazolium-ILs as solvent, along with piperidine-appended imidazolium [PAIM][NTf 2 ] as task-specific basic IL is demonstrated, without the need for any ligand or additive. The feasibility to perform these reactions by sequential one-pot iododediazoniation/decarboxylative Sonogashira reaction is also shown, and the scope of the methods is underscored by providing 29 examples. The potential for recycling and reuse of the IL solvent is also examined.

Publication Title

European Journal of Organic Chemistry

Volume

2019

Issue

10

First Page

2061

Last Page

2064

Digital Object Identifier (DOI)

10.1002/ejoc.201900093

ISSN

1434193X

E-ISSN

10990690

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