Extracellular vesicle-based drug delivery systems for cancer treatment

Authors

Sierra Walker, Mayo Clinic in Jacksonville, Florida
Sara Busatto, Mayo Clinic in Jacksonville, Florida
Anthony Pham, Mayo Clinic in Jacksonville, Florida
Ming Tian, Mayo Clinic in Jacksonville, Florida
Annie Suh, Mayo Clinic in Jacksonville, Florida
Kelsey Carson, University of North Florida
Astrid Quintero, University of North Florida
Maria Lafrence, University of North Florida
Hanna Malik, University of North Florida
Moises X. Santana, University of North Florida
Joy Wolfram, Mayo Clinic in Jacksonville, Florida

Document Type

Article

Publication Date

1-1-2019

Abstract

Extracellular vesicles (EVs) are naturally occurring cell-secreted nanoparticles that play important roles in many physiological and pathological processes. EVs enable intercellular communication by serving as delivery vehicles for a wide range of endogenous cargo molecules, such as RNAs, proteins, carbohydrates, and lipids. EVs have also been found to display tissue tropism mediated by surface molecules, such as integrins and glycans, making them promising for drug delivery applications. Various methods can be used to load therapeutic agents into EVs, and additional modification strategies have been employed to prolong circulation and improve targeting. This review gives an overview of EV-based drug delivery strategies in cancer therapy.

Publication Title

Theranostics

Volume

9

Issue

26

First Page

8001

Last Page

8017

Digital Object Identifier (DOI)

10.7150/thno.37097

PubMed ID

31754377

E-ISSN

18387640

Citation Information

Walker, Sierra; Busatto, Sara; Pham, Anthony; Tian, Ming; Suh, Annie; Carson, Kelsey; Quintero, Astrid; Lafrence, Maria; Malik, Hanna; Santana, Moises X.; and Wolfram, Joy, "Extracellular vesicle-based drug delivery systems for cancer treatment" (2019). UNF Faculty Research and Scholarship. 988.
https://digitalcommons.unf.edu/unf_faculty_publications/988