Libraries of C-5 Substituted Imidazoles and Oxazoles by Sequential Van Leusen (VL)–Suzuki, VL–Heck and VL–Sonogashira in Imidazolium-ILs with Piperidine-Appended-IL as Base
Document Type
Article
Publication Date
10-17-2018
Abstract
Facile access to diverse C5-substituted imidazoles and oxazoles via sequential Van Leusen–Suzuki, Van Leusen–Heck, and Van Leusen–Sonogashira protocols, employing imidazolium-ILs as solvents along with piperidine-appended imidazolium [PAIM][NTf2] as task-specific basic IL has been demonstrated, in a high-yielding one-pot method, starting with readily available aldimines (for imidazole) or aldehydes (for oxazole) and tosylmethylisocyanide (Tos-MIC), under mild conditions with potential for recycling and reuse of the IL solvent. The scope of the method is supported 49 examples.
Publication Title
European Journal of Organic Chemistry
Volume
2018
Issue
38
First Page
5285
Last Page
5288
Digital Object Identifier (DOI)
10.1002/ejoc.201800804
ISSN
1434193X
E-ISSN
10990690
Citation Information
Savanur, Kalkhambkar, R. G., & Laali, K. K. (2018). Libraries of C‐5 Substituted Imidazoles and Oxazoles by Sequential Van Leusen (VL)–Suzuki, VL–Heck and VL–Sonogashira in Imidazolium‐ILs with Piperidine‐Appended‐IL as Base. European Journal of Organic Chemistry, 2018(38), 5285–5288. https://doi.org/10.1002/ejoc.201800804