Title

Development of a clickable activity-based protein profiling (ABPP) probe for agmatine deiminases

Document Type

Article

Publication Date

5-1-2015

Abstract

Agmatine deiminases (AgDs) catalyze the hydrolytic conversion of agmatine (decarboxylated arginine) to N-carbamoylputrescine with concomitant release of ammonia. These enzymes, which are encoded by some pathogenic bacterial species, confer a competitive survival advantage by virtue of energy production and acid tolerance through agmatine catabolism. Herein we report the development of a clickable activity-based protein profiling (ABPP) probe that targets the AgD encoded by Streptococcus mutans with high selectivity and sensitivity.

Publication Title

Bioorganic and Medicinal Chemistry

Volume

23

Issue

9

First Page

2159

Last Page

2167

Digital Object Identifier (DOI)

10.1016/j.bmc.2015.03.013

PubMed ID

25819331

ISSN

09680896

E-ISSN

14643391

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