Schmidt reaction in ionic liquids: Highly efficient and selective conversion of aromatic and heteroaromatic aldehydes to nitriles with [BMIM(SO3H)][OTf] as catalyst and [BMIM][PF6] as solvent
Document Type
Article
Publication Date
4-24-2013
Abstract
A mild and selective method is presented for the conversion of aromatic and heteroaromatic aldehydes to nitriles via the Schmidt reaction with TMSN 3 by using [BMIM(SO3H)][OTf] as catalyst and [BMIM][PF6] as solvent. The method offers high yields and simple product isolation, and avoids the use of liquid superacids or corrosive Lewis acids commonly employed for this transformation. It also offers some potential for recycling/reuse of the IL solvent. © 2013 Elsevier Ltd. All rights reserved.
Publication Title
Tetrahedron Letters
Volume
54
Issue
17
First Page
2177
Last Page
2179
Digital Object Identifier (DOI)
10.1016/j.tetlet.2013.02.051
ISSN
00404039
E-ISSN
18733581
Citation Information
Nandi, & Laali, K. K. (2013). Schmidt reaction in ionic liquids: highly efficient and selective conversion of aromatic and heteroaromatic aldehydes to nitriles with [BMIM(SO3H)][OTf] as catalyst and [BMIM][PF6] as solvent. Tetrahedron Letters, 54(17), 2177–2179. https://doi.org/10.1016/j.tetlet.2013.02.051