Association of dual COVID-19 and seasonal influenza vaccination with COVID-19 infection and disease severity

Document Type

Article

Publication Date

1-23-2023

Subject Area

Adult; Humans; COVID-19 (prevention & control); Influenza, Human (prevention & control); COVID-19 Vaccines; Seasons; Influenza Vaccines; Vaccination; Patient Acuity

Abstract

The clinical guideline states that COVID-19 vaccination can be administered concurrently with Influenza (flu) vaccination (dual vaccination). Using data from the 2021 National Health Interview Survey, we conducted descriptive analysis and multivariate logistic regressions to examine the association between dual vaccination status and self-reported COVID-19 infection and severity. Among 21,387 (weighted 185,251,310) U.S. adults, about 22% did not receive either the flu or COVID-19 vaccine, 6.0% received the flu vaccine only, 29.1% received the COVID-19 vaccine only, and 42.5% received both vaccines. In the multivariate analysis, individuals with dual vaccination (OR, 0.65, 95% CI, 0.56-0.75) and COVID-19 vaccine only (OR, 0.71, 95% CI, 0.61-0.82) were significantly less likely to report COVID-19 infection when compared with those unvaccinated. There was no significant difference in self-reported COVID-19 symptom severity by vaccination status. The results suggest that dual vaccination may be an effective strategy to reduce the contagious respiratory disease burden.

Publication Title

Vaccine

Volume

41

Issue

4

First Page

875

Last Page

878

Digital Object Identifier (DOI)

10.1016/j.vaccine.2022.12.043

PubMed ID

36567142

E-ISSN

1873-2518

Language

eng

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