A Flexible Strategy for Modular Synthesis of Curcuminoid-BF2/Curcuminoid Pairs and Their Comparative Antiproliferative Activity in Human Cancer Cell Lines

Authors

Rodrigo Abonia, Universidad del Valle, Cali
Kenneth K. Laali, University of North FloridaFollow
Dawn Raja Somu, University of North Florida
Scott D. Bunge, Kent State University
Esther C. Wang, Kent State University

Document Type

Article

Publication Date

2-17-2020

Abstract

A facile protocol that enables synthetic interconversion of CUR-BF2 and CUR compounds is described that significantly widens the preparative scope of curcuminoids, providing access to larger libraries of compounds, thus enabling comparative antiproliferative and apoptotic study of a larger library of synthetic analogs in cancer cell lines.

Publication Title

ChemMedChem

Volume

15

Issue

4

First Page

354

Last Page

362

Digital Object Identifier (DOI)

10.1002/cmdc.201900640

PubMed ID

31875350

ISSN

18607179

E-ISSN

18607187

Citation Information

Abonia, R., Laali, K. K., Raja Somu, D., Bunge, S. D., & Wang, E. C. (2020). A Flexible Strategy for Modular Synthesis of Curcuminoid-BF2 /Curcuminoid Pairs and Their Comparative Antiproliferative Activity in Human Cancer Cell Lines. ChemMedChem, 15(4), 354–362. https://doi.org/10.1002/cmdc.201900640