Genomics of visceral pain
Document Type
Article
Publication Date
1-1-2020
Abstract
Visceral pain is one of the most common pain conditions and among the top causes of disability worldwide. Visceral pain may be associated with a specific pathology such as gastroenteritis, inflammatory conditions; however, most chronic visceral pain does not have an identifiable pathophysiological origin that is known. The characterization of visceral pain in terms of location, intensity, and severity of symptoms for phenotyping and investigation of underlying mechanisms is of upmost important to better understand not only the underlying mechanisms but ultimately the treatment for this chronic debilitating painful symptom. The following chapter will review the state-of-the-science on the genomics of visceral pain and comorbid symptoms (stress and sleep disturbance) and review methods of phenotyping visceral pain and the multi-omic methods for measurement. Additional focus will include current challenges and areas of future discovery.
Publication Title
Genomics of Pain and Co-Morbid Symptoms
First Page
111
Last Page
130
Digital Object Identifier (DOI)
10.1007/978-3-030-21657-3_9
ISBN
9783030216573,9783030216566
Citation Information
Henderson, W.A., Rahim-Williams, B. (2020). Genomics of Visceral Pain. In: Dorsey, S., Starkweather, A. (eds) Genomics of Pain and Co-Morbid Symptoms. Springer, Cham. https://doi.org/10.1007/978-3-030-21657-3_9