Joint effect of cognitive function and C-reactive protein on all-cause mortality risk: 1999-2002 NHANES

Document Type

Article

Publication Date

10-1-2022

Subject Area

Aged; Biomarkers (blood); C-Reactive Protein (analysis); Cognition (physiology); Cognitive Dysfunction (blood, mortality); Female; Humans; Male; Middle Aged; Nutrition Surveys; Risk Factors

Abstract

PURPOSE: Examine the joint effect of cognitive function and C-reactive protein (CRP) on all-cause mortality risk in older U.S. adults. METHODS: Sample included 1335 older adult (≥60 years of age) participants in the 1999-2002 National Health and Nutrition Examination Survey. A four-level variable was created using cognitive function and CRP concentration. Mortality was assessed using National Center for Health Statistics linked death records from the National Death Index. RESULTS: Increased risk of all-cause mortality was revealed in adults with high CRP and low cognitive function and in those with low to average CRP and low cognitive function (P < .0001 for both). Sex-stratified analyses revealed increased all-cause mortality risk in males with low cognitive function, independent of CRP concentration. However, in females, a significant increase in all-cause mortality risk was only observed in those with low to average CRP and low cognitive function. CONCLUSIONS: Low cognitive function was associated with increased all-cause mortality risk independent of CRP concentration. However, the joint effect of cognitive function and CRP on all-cause mortality risk differed according to sex.

Publication Title

Annals of epidemiology

Volume

74

First Page

111

Last Page

117

Digital Object Identifier (DOI)

10.1016/j.annepidem.2022.07.003

PubMed ID

35868614

E-ISSN

1873-2585

Language

eng

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